Jose Cordoba-Chacon, PhD.
2001-2004 - Bachelor of Science - Biology. University of Cordoba, Spain.
2004-2006 - Master of Science - Biochemistry. University of Cordoba, Spain.
2006-2007 - Master of Science - Biotechnology. University of Cordoba, Spain.
2007-2011 - Doctor of Phylosophy - Biomedicine. Dept. Cell Biology, Physiology and Inmunology. University of Cordoba, Spain. Mentors: Justo P. Castano PhD. and Raul M. Luque, PhD.
2011-2016 - Postoctoral training - Dept Medicine. Section of Endocrinology, Diabetes and Metabolism. University of Illinois at Chicago. Mentor: Rhonda D. Kineman, PhD.
Short Bio Heading link
I earned my BS (2004), MS (2006 & 2007) and PhD (2011) at the University of Cordoba (Spain). My PhD dissertation was focused on the regulation of growth hormone (GH) secretion by somatostatin, cortistatin and their receptors. LINK TO PHD DISSERTATION.
I continued my post-doctoral training in the laboratory of Dr. Kineman at the University of Illinois at Chicago where I studied the tissue-specific consequences of GH actions in adult mice using unique genetically engineered mouse models (2011-2017).
My skill portfolio expands a wide range of techniques and experimental approaches to examine integrative metabolism as it relates to the coordinate regulation of β-cell, muscle, adipose, gut and liver function. These studies led to the development of the lines of investigation in my independent research group.
My research group is focused on the understanding of the direct effects of PPARγ in hepatic lipid metabolism and its implication in non-alcoholic steatohepatitis (NASH). We have showed that hepatocyte PPARg regulates hepatocyte fatty acid (FA) translocase (Cd36)-mediated FA uptake and monoacylglycerol pathway-mediated FA esterification in order to promote hepatic steatosis in diet-induced obese mice (Wolf-Greenstein et al. J Endocrinol. 2017). Currently, we are altering the expression of PPARγ and its target genes in adult mice to determine the specific molecular mechanisms regulated by hepatocyte PPARγ that promote NASH. We have published two manuscripts related with this goal. (Cordoba-Chacon J. PPAR Res 2020, Lee et al. Cellular and Molecular Life Sciences 2021).
In addition, we are studying the role of conjugated linoleic acid (CLA) isomers on time and tissue-dependent changes, and their effects in the control of hepatic glucose production that may have a translational relevance for the control of patients with diabetes (Cordoba-Chacon et al. J Nutr Biochem. 2019). These studies are funded by UIC start-up funds and a K01-DK115525 (2018-2022).
Honors and Awards Heading link
2022 R01DK131038 (02/2022-01/2027) PPARgamma-regulated mechanisms in hepatocytes that promote NAFLD – NIH
2020 Early Career Development Award. Central Society for Clinical and Translational Research. WI.
2019 UI Health Diabetes Research Philanthropic Fund. UIC.
2019 P30-DK020595 AWD035726-03 (Sub00000060) (2019-2021) Suppression of hepatic glucose production by conjugated linoleic acid isomers. University of Chicago, Diabetes Training and Research Center
2018 K01DK115525 (02/2018-12/2022) Hepatocyte PPARgamma regulated mechanisms in NAFLD and lipid homeostasis – NIH
2015 PDR-033 Postdoctoral Research Award. Chicago Biomedical Consortium, Chicago. IL.
2014 Endocrine Scholar Award in Growth Hormone research. Endocrine Society, Washington, DC.
2012 Postdoctoral Fellowship. Alfonso Martin Escudero Foundation, Madrid, Spain.
2007 Predoctoral Fellowship. Institute of Health “Carlos III”, Spain.
a. Lee SM, et al. Endocrinology. 2021. 162(11):bqab175. PMID: 34417811 PMCID: PMC8428295
b. Lee SM, et al. Cellular and Molecular Gastroenterology and Hepatology. 2021. 11(5):1291-1311. PMID: 33444819 PMCID: PMC8005819.
c. Cordoba-Chacon J. PPAR Research 2020. 2020:9735083. PMID: 32411189 PMCID: PMC7211257
d. Cordoba-Chacon J et al. J Nutr Biochem. 2019. 67:90-100. PMID: 30856468 PMCID: PMC6520122.
2019-present Graduate College Faculty. Graduate College. University of Illinois at Chicago (UIC).
2018-present Departmental Affiliate. Department of Physiology and Biophysics. UIC.
2017-present Honors College Fellow. Honors College. UIC.
2017-2018 Visiting Instructor. Department of Medicine. UIC.
2017-present Member, Promoter Committee of Forum “UNICO”. University of Cordoba, Cordoba, Spain.
2014-2017 Research Scientist. Department of Medicine. UIC.
2011-2014 Visiting Research Specialist in Health Sciences. Department of Medicine. UIC.
2007-2011 Graduate Student. University of Cordoba, Cordoba, Spain.
Editorial Board Appointments
2022-present Editorial Board. Endocrinology. Endocrine Society
2020-2022 Early Career Reviewer. Endocrinology. Endocrine Society
2020-present Editorial Board. BMJ Open Diabetes Research & Care.
Committee Assignments and Administrative Services
2022 Reviewer Abstracts – ENDO2022 Annual meeting of the Endocrine Society
2022-present Co-Director of UI Health Diabetes Community Outreach. Department of Medicine. UIC.
2021 Ad hoc reviewer. CSME-CSR NIH October 12th-13th 2021
2021-present Scientific member. IACUC – Jesse Brown Veterans Affairs Medical Center, Chicago, IL
2020 Reviewer Abstracts – ENDO2021 Annual meeting of the Endocrine Society
2017-present Co-Director of Endocrinology Research Grand Rounds. Department of Medicine. UIC.
2014-2017 Scientific member. Animal Care committee (Small animal subcommittee). Institutional Animal Care and Use Committee (IACUC) University of Illinois at Chicago, Chicago, IL.
2020 Oral presentation. Endoonline 2020. Endocrine Society, Washington, DC.
2020 Summer Research Fellowship (Mentor of J. Muratalla). Endocrine Society, Washington, DC.
2020 Young investigator award. Obesity and Diabetes Research Day. UIC
2019 Outstanding Abstract Award, Endocrine Society, Washington, DC.
2019 Travel award. Central Society for Clinical and Translational Research. Milwaukee, WI.
2018 Early investigator award. Endocrine Society, Washington, DC.
2018 Summer Research Fellowship (Mentor of A. Tummala). Endocrine Society, Washington, DC.
Postdoctoral research associate
2015 Eugenia Rosenberg Abstract Award. Endocrine Society, Washington, DC.
2014 Travel award. Early Career Forum. Endocrine Society, Washington, DC.
2014 Winner of the Presidential Poster Competition. Endocrine Society, Washington, DC.
2014 Trainee travel award. Central Society for Clinical and Translational Research. Milwaukee, WI.
2012 Outstanding PhD dissertation Award of 2011, University of Cordoba, Cordoba, Spain.
2012 PhD dissertation Award, University of Cordoba, Cordoba, Spain.
2006 Outstanding MS in Biochemistry Award, University of Cordoba, Cordoba, Spain